There are a series of Optionals that can be enabled later during the playthrough, or to fix issues and bugs. Most of these contain some capacity for cheating or making the game easier. For the same reason, mods such as Automate, the Tractor Mod and mods for Multiple Spouses are disabled until needed. I would suggest turning Automate after Year 1, the Tractor Mod upon unlocking the Ginger Island farm, and FreeLove or PolyamorySweet on (choose one) when the farmer is ready for a second spouse. If romancing the Wizard (RRRR), wait until both children are fully grown and year 4 before marrying anyone else. If not romancing the Wizard, disable this mod in the Individual NPC Enhancements section All Fashion Sense and Alternative Texture mods can be enabled and disabled at any time, though its recommended to change away from those textures/clothing pieces before removing the related mods.